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Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study

Kirkegaard-Klitbo, DM; Fuchs, A; Stender, S; Sigvardsen, PE; Kühl, JT; Kofoed, KF; Køber, L; ... Benfield, T; + view all (2020) Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study. Journal of Infectious Diseases 10.1093/infdis/jiaa246. (In press).

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Abstract

BACKGROUND: People living with HIV (PWH) may be at risk of non-alcoholic fatty liver disease (NAFLD). We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with HIV-uninfected controls and determined risk factors for M-HS in PWH. METHODS: The Copenhagen Co-Morbidity in HIV infection Study included 453 participants and the Copenhagen General Population Study 765 participants. None had prior or current viral hepatitis or excessive alcohol intake. M-HS was assessed by unenhanced CT liver scan defined by liver attenuation ≤48 Hounsfield units. Adjusted odds ratios (aOR) were computed by adjusted logistic regression. RESULTS: The prevalence of M-HS was lower in PWH compared to uninfected controls (8.6% vs. 14.2%, p<0.01). In multivariable analyses, HIV (aOR:0.44, p<0.01); female sex (aOR:0.08, p=0.03); physical activity level (aOR 0.09 very active vs inactive, p<0.01); and alcohol (aOR:0.89 per unit/week, p=0.02) was protective factors, while BMI (aOR:1.58 per 1 kg/m2, p<0.01); ALT (aOR:1.76 per 10 U/L, p<0.01); and exposure to integrase inhibitors (aOR: 1.28 per year, p=0.02) were associated with higher odds of M-HS. CONCLUSIONS: Moderate-to-severe hepatic steatosis is less common in PWH compared to demographically comparable uninfected controls. Besides BMI and ALT, integrase inhibitor exposure was associated with higher prevalence of steatosis in PWH.

Type: Article
Title: Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study
Location: United States
DOI: 10.1093/infdis/jiaa246
Publisher version: http://dx.doi.org/10.1093/infdis/jiaa246
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: NAFL, NAFLD, comorbidity, fatty liver disease, human immunodeficiency virus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/10099362
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