Samuels, Michael L.; (1999) Yeast stress signalling. Doctoral thesis (Ph.D.), University College London (United Kingdom).

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Abstract

Environmental stress is a common challenge for all cells, requiring that appropriate responses be made to ensure survival. Mechanisms developed for coupling stress signalling to the basic transcriptional apparatus allow for response gene activation and are likely to have been conserved throughout evolution. This hypothesis is explored during an examination of a kinase cascade that signals stress conditions via transcription factors to the genome of the yeast Schizosaccharomyces pombe. Analysis of interactions between the MAP kinase Sty1 and the bZip transcription factors Atf1 and Pap1 define clear stress signalling pathways leading to the induction of a number of identified response genes. Many similarities have been found between this yeast and both budding yeast and mammalian signalling cascades, including a surprising high degree of homology in the protein factors and gene targets used for response generation. Transcription in yeast and mammalian cells almost certainly follows the same fundamental principles, although there is no doubt that mammalian cells need to integrate responses to more complicated and diverse regulatory signals. The use of Schizosaccharomyces pombe as a simple and genetically tractable model organism should help to provide a clearer understanding of complex mammalian signalling networks.

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