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Associations between widespread pain and sleep quality in people with HIV

Sabin, CA; Harding, R; Doyle, N; Redline, S; Francesco, DDE; Mallon, PW; Post, FA; ... Kunisaki, KM; + view all (2020) Associations between widespread pain and sleep quality in people with HIV. Journal of Acquired Immune Deficiency Syndromes 10.1097/QAI.0000000000002410. (In press).

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Abstract

BACKGROUND: We investigate the association of widespread pain with sleep quality among people with HIV (PWH) and HIV-negative controls. SETTING: UK-based cohort. METHODS: Pain information was collected through a pain mannikin identifying affected body sites; pain was classified as widespread if pain was reported in >4 of 5 body regions and in >7 of 15 body sites, and as regional otherwise. Sleep was assessed a median of 3.2 years later though 7-night actigraphy and through self-reported assessments of sleep quality. Chi-squared tests, Kruskal-Wallace tests and linear/logistic regression considered associations between pain extent and sleep quality. RESULTS: Of the 414 participants, 74 (17.9%) reported widespread and 189 (45.7%) regional pain. Whilst there were few clear associations between actigraphy outcomes and pain extent, those with widespread and regional pain consistently reported poorer sleep quality on all self-reported measures than those with no pain. Median (interquartile range) insomnia severity index and Patient-reported Outcomes Measurement Information System (PROMIS) for sleep disturbance and sleep-related impairment scores were 12 (7-16), 55.3 (48.0-58.9) and 57.2 (48.9-61.3) respectively for those with widespread pain, 8 (4-13), 51.2 (45.5-58.3) and 50.3 (43.6-56.1) for those with regional pain, and 5 (2-9), 47.9 (42.9-54.3) and 45.5 (41.4-50.3) for those with no pain (all p-values 0.0001). Associations remained strong after adjustment for HIV status and other confounders, and were reduced but remained significant, after adjustment for depressive symptoms. CONCLUSIONS: Widespread pain was not associated with objective measures of sleep but was strongly associated with self-reported assessments of sleep quality in PWH.

Type: Article
Title: Associations between widespread pain and sleep quality in people with HIV
Location: United States
DOI: 10.1097/QAI.0000000000002410
Publisher version: https://doi.org/10.1097/QAI.0000000000002410
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10099231
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