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Systemic amyloidosis: moving into the spotlight

Cohen, OC; Wechalekar, AD; (2020) Systemic amyloidosis: moving into the spotlight. Leukemia , 34 (5) pp. 1215-1228. 10.1038/s41375-020-0802-4. Green open access

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Abstract

Systemic amyloidosis is a rare but increasingly recognised disease that is heterogeneous in presentation. Early diagnosis, whilst imperative, remains challenging but can improve prognosis and limit organ dysfunction. An increased repertoire of diagnostic imaging and histological techniques are becoming mainstream and promise to aid early diagnosis. Better risk stratification, via biomarkers and cytogenetics, has improved multidisciplinary treatment decisions. The use of novel agents has improved treatment efficacy, which translates into survival benefit. Newer strategies targeting pre-deposited amyloidogenic protein are under investigation. The current paper reviews available data relating to the most recent advances in the field of systemic amyloidosis.

Type: Article
Title: Systemic amyloidosis: moving into the spotlight
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41375-020-0802-4
Publisher version: http://dx.doi.org/10.1038/s41375-020-0802-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: LIGHT-CHAIN AMYLOIDOSIS, STEM-CELL TRANSPLANTATION, HIGH-DOSE MELPHALAN, AL AMYLOIDOSIS, TRANSTHYRETIN AMYLOIDOSIS, HEMATOLOGIC RESPONSES, MULTIPLE-MYELOMA, NT-PROBNP, DEXAMETHASONE, BORTEZOMIB
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10099077
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