Moore, EE;
Gifford, KA;
Khan, OA;
Liu, D;
Pechman, KR;
Acosta, LMY;
Bell, SP;
... Jefferson, AL; + view all
(2020)
Cerebrospinal fluid biomarkers of neurodegeneration, synaptic dysfunction, and axonal injury relate to atrophy in structural brain regions specific to Alzheimer's disease.
Alzheimer’s & Dementia
, 16
(6)
pp. 883-895.
10.1002/alz.12087.
Preview |
Text
Zetterberg_Moore.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Introduction: Patterns of atrophy can distinguish normal cognition from Alzheimer's disease (AD), but neuropathological drivers of this pattern are unknown. This study examined associations between cerebrospinal fluid biomarkers of AD pathology, synaptic dysfunction, and neuroaxonal injury with two AD imaging signatures. / Methods: Signatures were calculated using published guidelines. Linear regressions related each biomarker to both signatures, adjusting for demographic factors. Bootstrapped analyses tested if associations were stronger with one signature versus the other. / Results: Increased phosphorylated tau (p‐tau), total tau, and neurofilament light (P ‐values <.045) related to smaller signatures (indicating greater atrophy). Diagnosis and sex modified associations between p‐tau and neurogranin (P ‐values<.05) and signatures, such that associations were stronger among participants with mild cognitive impairment and female participants. The strength of associations did not differ between signatures. / Discussion: Increased evidence of neurodegeneration, axonopathy, and tau phosphorylation relate to greater AD‐related atrophy. Tau phosphorylation and synaptic dysfunction may be more prominent in AD‐affected regions in females.
| Type: | Article |
|---|---|
| Title: | Cerebrospinal fluid biomarkers of neurodegeneration, synaptic dysfunction, and axonal injury relate to atrophy in structural brain regions specific to Alzheimer's disease |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12087 |
| Publisher version: | https://doi.org/10.1002/alz.12087 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | AD signature, cerebrospinal fluid, cortical thickness, sex differences |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10098430 |
Archive Staff Only
 |
View Item |
