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Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer

An, Z; Flores-Borja, F; Irshad, S; Deng, J; Ng, T; (2020) Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer. Frontiers in Immunology , 10 , Article 3111. 10.3389/fimmu.2019.03111. Green open access

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Abstract

Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the environmental signals from surrounding tissues and other immune cells. The pleiotropic function of ILCs in diverse contexts underpins its importance in the innate arm of immune system in human health and disease. ILCs derive from common lymphoid progenitors but lack adaptive antigen receptors and functionally act as the innate counterpart to T-cell subsets. The classification of different subtypes is based on their distinct transcription factor requirement for development as well as signature cytokines that they produce. The discovery and subsequent characterization of ILCs over the past decade have mainly focused on the regulation of inflammation, tissue remodeling, and homeostasis, whereas the understanding of the multiple roles and mechanisms of ILCs in cancer is still limited. Emerging evidence of the potent immunomodulatory properties of ILCs in early host defense signifies a major advance in the use of ILCs as promising targets in cancer immunotherapy. In this review, we will decipher the non-exclusive roles of ILCs associated with both protumor and antitumor activities. We will also dissect the heterogeneity, plasticity, genetic evidence, and dysregulation in different cancer contexts, providing a comprehensive understanding of the complexity and diversity. These will have implications for the therapeutic targeting in cancer.

Type: Article
Title: Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2019.03111
Publisher version: https://doi.org/10.3389/fimmu.2019.03111
Language: English
Additional information: Copyright © 2020 An, Flores-Borja, Irshad, Deng and Ng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: ILCs, cancer, tumor immune microenvironment, immunosurveillance, heterogenity, plasticicity, immunotherapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10098377
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