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Targeting mitochondrial fusion and fission proteins for cardioprotection

Hernandez-Resendiz, S; Prunier, F; Girao, H; Dorn, G; Hausenloy, DJ; EU-CARDIOPROTECTION COST Action (CA16225); (2020) Targeting mitochondrial fusion and fission proteins for cardioprotection. Journal of Cellular and Molecular Medicine 10.1111/jcmm.15384. (In press). Green open access

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Abstract

New treatments are needed to protect the myocardium against the detrimental effects of acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in order to limit myocardial infarct (MI) size, preserve cardiac function and prevent the onset of heart failure (HF). Given the critical role of mitochondria in energy production for cardiac contractile function, prevention of mitochondrial dysfunction during acute myocardial IRI may provide novel cardioprotective strategies. In this regard, the mitochondrial fusion and fissions proteins, which regulate changes in mitochondrial morphology, are known to impact on mitochondrial quality control by modulating mitochondrial biogenesis, mitophagy and the mitochondrial unfolded protein response. In this article, we review how targeting these inter-related processes may provide novel treatment targets and new therapeutic strategies for reducing MI size, preventing the onset of HF following AMI.

Type: Article
Title: Targeting mitochondrial fusion and fission proteins for cardioprotection
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcmm.15384
Language: English
Additional information: © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: acute myocardial ischaemia/reperfusion injury, cardioprotection, mitochondrial morphology, mitochondrial unfolded protein response, mitophagy cardioprotection
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10098115
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