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Characteristics of novel Ti–10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications

Xu, W; Hou, C; Mao, Y; Yang, L; Tamaddon, M; Zhang, J; Qu, X; ... Lu, X; + view all (2020) Characteristics of novel Ti–10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications. Bioactive Materials , 5 (3) pp. 659-666. 10.1016/j.bioactmat.2020.04.012. Green open access

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Abstract

When biomaterials are implanted in the human body, the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation, causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery. Ti–Mo alloy is one of the commonly used implant materials for load-bearing bone replacement, and the prevention of infection of Ti–Mo implants is therefore crucial. In this study, bacterial inhibitory copper (Cu) was added to Ti–Mo matrix to develop a novel Ti–Mo–Cu alloy with bacterial inhibitory property. The effects of Cu content on microstructure, tensile properties, cytocompatibility, and bacterial inhibitory ability of Ti–Mo–Cu alloy were systematically investigated. Results revealed that Ti–10Mo–1Cu alloy consisted of α and β phases, while there were a few Ti_{2}Cu intermetallic compounds existed for Ti–10Mo–3Cu and Ti–10Mo–5Cu alloys, in addition to α and β phases. The tensile strength of Ti–10Mo-xCu alloy increased with Cu content while elongation decreased. Ti–10Mo–3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%. Cytocompatibility study indicated that none of the Ti–10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation. Bacterial inhibitory rates against S. aureus and E. coli increased with the increase in Cu content of Ti–10Mo-xCu alloy, within the ranges of 20–60% and 15–50%, respectively. Taken together, this study suggests that Ti–10Mo–3Cu alloy with high strength, acceptable elongation, excellent cytocompatibility, and the bacterial inhibitory property is a promising candidate for biomedical implant applications.

Type: Article
Title: Characteristics of novel Ti–10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bioactmat.2020.04.012
Publisher version: https://doi.org/10.1016/j.bioactmat.2020.04.012
Language: English
Additional information: © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Keywords: Ti-10Mo-xCu alloy, Microstructure, Mechanical properties, Cytocompatibility, Bacterial inhibitory property
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10097711
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