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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

Ashton, NJ; Hye, A; Rajkumar, AP; Leuzy, A; Snowden, S; Suarez-Calvet, M; Karikari, TK; ... Aarsland, D; + view all (2020) An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders. Nature Reviews Neurology , 16 (5) pp. 265-284. 10.1038/s41582-020-0348-0. Green open access

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Abstract

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-sensitive assays have enabled the levels of pathological proteins to be measured in blood samples, but research has been predominantly focused on Alzheimer disease (AD). Nonetheless, proteins that were identified as potential blood-based biomarkers for AD, for example, amyloid-β, tau, phosphorylated tau and neurofilament light chain, are likely to be relevant to other neurodegenerative disorders that involve similar pathological processes and could also be useful for the differential diagnosis of clinical symptoms. This Review outlines the neuropathological, clinical, molecular imaging and cerebrospinal fluid features of the most common neurodegenerative disorders outside the AD continuum and gives an overview of the current status of blood-based biomarkers for these disorders.

Type: Article
Title: An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41582-020-0348-0
Publisher version: https://doi.org/10.1038/s41582-020-0348-0
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Diagnostic markers, Prognostic markers
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10097595
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