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Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural

Siu, J; Motallebzadeh, R; Pettigrew, G; (2020) Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural. Cellular Immunology , 354 , Article 104131. 10.1016/j.cellimm.2020.104131. Green open access

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Abstract

Non-HLA antibody responses following solid organ transplantation have become increasingly emphasised, with several large clinical series suggesting that such responses contribute to late graft failure. Many of the responses described recognise both recipient and donor moieties of the target antigen and thus represent auto-, rather than allo-immunity. Within this rapidly evolving field, many questions remain unanswered: what triggers the response; how innate and adaptive humoral autoimmunity integrate; and most pressingly, how autoimmunity contributes to graft damage and its relationship to other effector mechanisms of graft rejection. This review summarises recent clinical and experimental studies of humoral autoimmunity in transplant rejection, and considers some of the answers to these questions.

Type: Article
Title: Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cellimm.2020.104131
Publisher version: https://doi.org/10.1016/j.cellimm.2020.104131
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10097471
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