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Microscopic susceptibility anisotropy imaging

Kaden, E; Gyori, NG; Rudrapatna, SU; Barskaya, IY; Dragonu, I; Does, MD; Jones, DK; ... Alexander, DC; + view all (2020) Microscopic susceptibility anisotropy imaging. Magnetic Resonance in Medicine 10.1002/mrm.28303. (In press). Green open access

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Abstract

PURPOSE: The gradient-echo MR signal in brain white matter depends on the orientation of the fibers with respect to the external magnetic field. To map microstructure-specific magnetic susceptibility in orientationally heterogeneous material, it is thus imperative to regress out unwanted orientation effects. METHODS: This work introduces a novel framework, referred to as microscopic susceptibility anisotropy imaging, that disentangles the 2 principal effects conflated in gradient-echo measurements, (a) the susceptibility properties of tissue microenvironments, especially the myelin microstructure, and (b) the axon orientation distribution relative to the magnetic field. Specifically, we utilize information about the orientational tissue structure inferred from diffusion MRI data to factor out the B 0 -direction dependence of the frequency difference signal. RESULTS: A human pilot study at 3 T demonstrates proxy maps of microscopic susceptibility anisotropy unconfounded by fiber crossings and orientation dispersion as well as magnetic field direction. The developed technique requires only a dual-echo gradient-echo scan acquired at 1 or 2 head orientations with respect to the magnetic field and a 2-shell diffusion protocol achievable on standard scanners within practical scan times. CONCLUSIONS: The quantitative recovery of microscopic susceptibility features in the presence of orientational heterogeneity potentially improves the assessment of microstructural tissue integrity.

Type: Article
Title: Microscopic susceptibility anisotropy imaging
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mrm.28303
Publisher version: http://dx.doi.org/10.1002/mrm.28303
Language: English
Additional information: © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: brain white matter, gradient-echo MR imaging, microscopic frequency shift, orientational tissue heterogeneity, spherical mean technique (SMT)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10097308
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