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Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners

Tunbak, H; Vazquez-Prada, MC; Ryan, TM; Kampff, AR; Dreosti, E; (2020) Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners. eLife , 9 , Article e55863. 10.7554/eLife.55863. (In press). Green open access

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Abstract

The zebrafish was used to assess the impact of social isolation on behaviour and brain function. As in humans and other social species, early social deprivation reduced social preference in juvenile zebrafish. Whole-brain functional maps of anti-social isolated (lonely) fish were distinct from anti-social (loner) fish found in the normal population. These isolation-induced activity changes revealed profound disruption of neural activity in brain areas linked to social behaviour, social cue processing, and anxiety/stress. Several of the affected regions are modulated by serotonin, and we found that social preference in isolated fish could be rescued by acutely reducing serotonin levels.

Type: Article
Title: Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.55863
Publisher version: https://doi.org/10.7554/eLife.55863
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Neuroscience, zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10097237
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