Salunke, S;
Alessandrini, E;
Amin, D;
Kaneria, N;
Andrews, D;
Liu, J;
Tuleu, C;
(2020)
Can One Teach Old Drugs New Tricks? Reformulating to Repurpose Chloroquine and Hydroxychloroquine.
Journal of Pharmacology and Pharmaceutical Research
, 3
(1)
pp. 1-8.
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Abstract
The outbreak of the novel corona virus disease, COVID-19, has presented health care professionals with the unique challenges of trying to select appropriate pharmacological treatments with little time available for drug testing. Given the development times and manufacturing requirements for new products, Value Added Medicines (repurposing – reformulation of existing drugs) could be one possibility to beat the COVID-19 outbreak. This review explores reformulation alternatives which could be progressed with chloroquine and hydroxychloroquine; two antimalarial drugs, that are being tested on a global scale as a potential therapeutic option. The key areas for improvement have been reviewed and the potential solutions to the problems and limitations of current formulations are discussed. The pharmaceutical challenges discussed are those of highly soluble drugs, needed to be given at high doses and presenting a real bitter taste challenge with significant gastrointestinal side effects that could be translated and repurposed into fit for purpose reformulations.
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