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Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?

Awan, M; Buriak, I; Fleck, R; Fuller, B; Goltsev, A; Kerby, J; Lowdell, M; ... Stacey, GN; + view all (2020) Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? Regenerative Medicine , 15 (3) 10.2217/rme-2019-0145. Green open access

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Abstract

Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.

Type: Article
Title: Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/rme-2019-0145
Publisher version: https://doi.org/10.2217/rme-2019-0145
Language: English
Additional information: This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: cell therapy, cell therapy safety, cryobiology, cryopreservation, cryoprotectants, cryoprotectant toxicity, dimethyl sulfoxide, DMSO toxicity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10096823
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