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Association Between a Directly Translated Cognitive Measure of Negative Bias and Self-reported Psychiatric Symptoms

Daniel-Watanabe, L; McLaughlin, M; Gormley, S; Robinson, OJ; (2020) Association Between a Directly Translated Cognitive Measure of Negative Bias and Self-reported Psychiatric Symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 10.1016/j.bpsc.2020.02.010. (In press). Green open access

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Abstract

BACKGROUND: Negative interpretation biases are thought to be core symptoms of mood and anxiety disorders. However, prior work using cognitive tasks to measure such biases is largely restricted to case-control group studies, which cannot be used for inference about individuals without considerable additional validation. Moreover, very few measures are fully translational (i.e., can be used across animals and humans in treatment-development pipelines). This investigation aimed to produce the first measure of negative cognitive biases that is both translational and sensitive to individual differences, and then to determine which specific self-reported psychiatric symptoms are related to bias. METHODS: A total of 1060 (n = 990 complete) participants performed a cognitive task of negative bias along with psychiatric symptom questionnaires. We tested the hypothesis that individual levels of mood and anxiety disorder symptomatology would covary positively with negative bias on the cognitive task using a combination of computational modeling of behavior, confirmatory factor analysis, exploratory factor analysis, and structural equation modeling. RESULTS: Participants with higher depression symptoms (β = −.16, p = .017) who were older (β = −.11, p = .001) and had lower IQ (β = .14, p < .001) showed greater negative bias. Confirmatory factor analysis and structural equation modeling suggested that no other psychiatric symptom (or transdiagnostic latent factor) covaried with task performance over and above the effect of depression, while exploratory factor analysis suggested combining depression/anxiety symptoms in a single latent factor. Generating groups using symptom cutoffs or latent mixture modeling recapitulated our prior case-control findings. CONCLUSIONS: This measure, which uniquely spans both the clinical group-to-individual and preclinical animal-to-human generalizability gaps, can be used to measure individual differences in depression vulnerability for translational treatment-development pipelines.

Type: Article
Title: Association Between a Directly Translated Cognitive Measure of Negative Bias and Self-reported Psychiatric Symptoms
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpsc.2020.02.010
Publisher version: https://doi.org/10.1016/j.bpsc.2020.02.010
Language: English
Additional information: © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Anxiety, Computational psychiatry, Depression, Individual differences, Negative affective bias, Online testing, Structural equation modeling
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10096632
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