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Burden of anal squamous cell carcinoma, squamous intraepithelial lesions and HPV16 infection in solid organ transplant recipients: A systematic review and meta-analysis

Albuquerque, A; Stirrup, O; Nathan, M; Clifford, GM; (2020) Burden of anal squamous cell carcinoma, squamous intraepithelial lesions and HPV16 infection in solid organ transplant recipients: A systematic review and meta-analysis. American Journal of Transplantation 10.1111/ajt.15942. (In press).

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Abstract

The number of solid organ transplant recipients (SOTR), and their life expectancy, is increasing, with higher risk for long-term complications from immunosuppression. We carried out a systematic review describing the burden of anal squamous cell carcinoma (SCC), and its surrogates, in SOTR. We conducted mixed effect model-based meta-analyses evaluating incidence of anal SCC [standardised incidence ratio (SIR) versus general population, and absolute incidence rate (IR)], prevalence of anal squamous abnormalities and human papillomavirus (HPV) 16. Generalised I2 statistics were calculated, quantifying heterogeneity. Anal SCC incidence in SOTR was elevated versus the general population (pooled SIR = 6.8, 95% CI 4.3-10.9; six studies including 241,106 SOTR; I2 =82.3%), with an absolute IR of 12.3 (95% CI 10.4-14.7) per 100,000 person-years (five studies including 1,079,489 person-years; I2 =0%). Prevalence of abnormal anal cytology was 12.9% (95% CI 9.2-17.7%; six studies including 328 SOTR; I2 =17.4%). For histology, the pooled prevalence estimate of anal squamous intraepithelial lesions was 22.4% (95% CI 17.3-28.5%; three studies including 214 SOTR; I2 =0%), with 4.7% (95% CI 2.5-8.5%; I2 =0%) high-grade squamous intraepithelial lesions. Pooled anal HPV16 prevalence was 3.6% (95% CI 1.6-7.8%; four studies including 254 SOTR; I2 =17.6%). There was substantial and consistent evidence of elevated anal SCC incidence in SOTR.

Type: Article
Title: Burden of anal squamous cell carcinoma, squamous intraepithelial lesions and HPV16 infection in solid organ transplant recipients: A systematic review and meta-analysis
Location: United States
DOI: 10.1111/ajt.15942
Publisher version: http://dx.doi.org/10.1111/ajt.15942
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10096620
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