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The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection

Fernandes, VE; Ercoli, G; Bénard, A; Brandl, C; Fahnenstiel, H; Müller-Winkler, J; Weber, GF; ... Andrew, PW; + view all (2020) The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLOS Pathogens , 16 (4) , Article e1008464. 10.1371/journal.ppat.1008464. Green open access

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Abstract

Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.

Type: Article
Title: The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.ppat.1008464
Publisher version: https://doi.org/10.1371/journal.ppat.1008464
Language: English
Additional information: Copyright © 2020 Fernandes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: B cells, Spleen, Pneumococcus, Escherichia coli infections, Respiratory infections, Blood, Genetic loci, Streptococcal infections
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10096408
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