Fernandes, VE; Ercoli, G; Bénard, A; Brandl, C; Fahnenstiel, H; Müller-Winkler, J; Weber, GF; ... Andrew, PW; + view all Fernandes, VE; Ercoli, G; Bénard, A; Brandl, C; Fahnenstiel, H; Müller-Winkler, J; Weber, GF; Denny, P; Nitschke, L; Andrew, PW; - view fewer (2020) The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLOS Pathogens , 16 (4) , Article e1008464. 10.1371/journal.ppat.1008464.

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Abstract

Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.

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