Fernandes, VE;
Ercoli, G;
Bénard, A;
Brandl, C;
Fahnenstiel, H;
Müller-Winkler, J;
Weber, GF;
... Andrew, PW; + view all
(2020)
The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection.
PLOS Pathogens
, 16
(4)
, Article e1008464. 10.1371/journal.ppat.1008464.
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Abstract
Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.
| Type: | Article |
|---|---|
| Title: | The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.ppat.1008464 |
| Publisher version: | https://doi.org/10.1371/journal.ppat.1008464 |
| Language: | English |
| Additional information: | Copyright © 2020 Fernandes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | B cells, Spleen, Pneumococcus, Escherichia coli infections, Respiratory infections, Blood, Genetic loci, Streptococcal infections |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10096408 |
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