UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma

Hanna, DL; Law, SJ; Merrick, SA; Heptinstall, L; Bass, P; Dupont, P; Sheri, A; (2020) The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma. Melanoma Research , 30 (3) pp. 321-324. 10.1097/cmr.0000000000000651. Green open access

[thumbnail of The successful use of Pembrolizumab in a renal transplant recipient with metastatic melanoma.pdf]
Preview
Text
The successful use of Pembrolizumab in a renal transplant recipient with metastatic melanoma.pdf - Accepted Version

Download (569kB) | Preview

Abstract

We report a case in which a renal transplant recipient with metastatic melanoma had an excellent response to treatment with second line programmed cell death protein 1 (PD-1) inhibitor therapy, pembrolizumab. Acute cellular allograft rejection on initiation of PD-1 inhibitor was successfully reversed with methylprednisolone. By converting the patient to sirolimus and giving predose prednisolone, pembrolizumab was continued with stable renal function and an excellent oncological response. This case supports the efficacy of PD-1 inhibitors in patients who are chronically immunosuppressed, and suggests an approach to maintain transplant function.

Type: Article
Title: The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/cmr.0000000000000651
Publisher version: https://doi.org/10.1097/cmr.0000000000000651
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Checkpoint inhibitors, renal transplant, Pembrolizumab, PD-1 inhibitor, Ipilimumab, CTLA-4 antagonist
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10095879
Downloads since deposit
147Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item