Hanna, DL;
Law, SJ;
Merrick, SA;
Heptinstall, L;
Bass, P;
Dupont, P;
Sheri, A;
(2020)
The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma.
Melanoma Research
, 30
(3)
pp. 321-324.
10.1097/cmr.0000000000000651.
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Abstract
We report a case in which a renal transplant recipient with metastatic melanoma had an excellent response to treatment with second line programmed cell death protein 1 (PD-1) inhibitor therapy, pembrolizumab. Acute cellular allograft rejection on initiation of PD-1 inhibitor was successfully reversed with methylprednisolone. By converting the patient to sirolimus and giving predose prednisolone, pembrolizumab was continued with stable renal function and an excellent oncological response. This case supports the efficacy of PD-1 inhibitors in patients who are chronically immunosuppressed, and suggests an approach to maintain transplant function.
| Type: | Article |
|---|---|
| Title: | The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/cmr.0000000000000651 |
| Publisher version: | https://doi.org/10.1097/cmr.0000000000000651 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Checkpoint inhibitors, renal transplant, Pembrolizumab, PD-1 inhibitor, Ipilimumab, CTLA-4 antagonist |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10095879 |
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