Roberts, SE;
Thorne, K;
Thapar, N;
Broekaert, I;
Benninga, MA;
Dolinsek, J;
Mas, E;
... Williams, JG; + view all
(2020)
A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe.
Journal of Crohn's and Colitis
, 14
(8)
pp. 1119-1148.
10.1093/ecco-jcc/jjaa037.
Preview |
Text
jjaa037.pdf - Accepted Version Download (3MB) | Preview |
Abstract
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is often one of the most devastating and debilitating chronic gastrointestinal disorders in children and adolescents. The main objectives were to systematically review the incidence and prevalence of paediatric inflammatory bowel disease across all 51 European states. METHODS: A systematic review and meta analysis based on PubMed, CINAHL, the Cochrane Library, searches of reference lists, grey literature and websites, covering the period from 1970 to 2018. RESULTS: Incidence rates for both paediatric Crohn's disease (CD) and ulcerative colitis (UC) were higher in northern Europe than in other European regions. There have been large increases in the incidence of both paediatric CD and UC over the last 50 years, which appear widespread across Europe. The largest increases for CD have been reported from Sweden, Wales, England, the Czech Republic, Denmark and Hungary, and for UC from the Czech Republic, Ireland, Sweden and Hungary.Incidence rates for paediatric CD have increased up to 9 or 10 per 100 000 population in parts of Europe, including Scandinavia, while rates for paediatric UC are often slightly lower than for CD. Prevalence reported for CD ranged from 8.2 per 100 000 to approximately 60 and, for UC, from 8.3 to approximately 30. CONCLUSIONS: The incidence of paediatric IBD continues to increase throughout Europe. There is stronger evidence of a north: south than an east: west gradient in incidence across Europe. Further prospective studies are needed, preferably multinational and based on IBD registries, using standardised definitions, methodology and timescales.
| Type: | Article |
|---|---|
| Title: | A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ecco-jcc/jjaa037 |
| Publisher version: | https://doi.org/10.1093/ecco-jcc/jjaa037 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Europe, Inflammatory bowel disease, incidence, paediatric, trends |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10095769 |
Archive Staff Only
 |
View Item |
