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CSF α-synuclein correlates with CSF neurogranin in late-life depression

Bruno, D; Plaska, CR; Clark, DPA; Zetterberg, H; Blennow, K; Verbeek, MM; Pomara, N; (2021) CSF α-synuclein correlates with CSF neurogranin in late-life depression. International Journal of Neuroscience , 131 (4) pp. 357-361. 10.1080/00207454.2020.1744596. Green open access

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Abstract

PURPOSE/AIM OF THE STUDY: Major depressive disorder (MDD) in late life is linked to increased risk of subsequent dementia, but it is still unclear exactly what pathophysiological mechanisms underpin this link. A potential mechanism related to elevated risk of dementia in MDD is increased levels of α-synuclein (α-Syn), a protein found in presynaptic neuronal terminals. MATERIALS AND METHODS: In this study, we examined cerebrospinal fluid (CSF) levels of α-Syn in conjunction with biomarkers of neurodegeneration (amyloid-β 42, total and phospho tau) and synaptic dysfunction (neurogranin), and measures of memory ability, in 27 cognitively intact older individuals with MDD and 19 controls. RESULTS: Our results show that CSF α-Syn levels did not significantly differ across depressed and control participants, but α-Syn was directly associated with neurogranin levels, and indirectly linked to poorer memory ability. CONCLUSIONS: All in all, we found that α-Syn may be implicated in the association between late life MDD and synaptic dysfunction, although further research is needed to confirm these results.

Type: Article
Title: CSF α-synuclein correlates with CSF neurogranin in late-life depression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/00207454.2020.1744596
Publisher version: https://doi.org/10.1080/00207454.2020.1744596
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: α-synuclein, late-life major depressive disorder, neurogranin, memory
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10095690
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