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Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

Platel, J-C; Angelova, A; Bugeon, S; Wallace, J; Ganay, T; Chudotvorova, I; Deloulme, J-C; ... Cremer, H; + view all (2019) Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process. eLife , 8 , Article e44830. 10.7554/eLife.44830. Green open access

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Abstract

Adult neurogenesis in the olfactory bulb (OB) is considered as a competition in which neurons scramble during a critical selection period for integration and survival. Moreover, newborn neurons are thought to replace pre-existing ones that die. Despite indirect evidence supporting this model, systematic in vivo observations are still scarce. We used two-photon in vivo imaging to study neuronal integration and survival. We show that loss of new neurons in the OB after arrival at terminal positions occurs only at low levels. Moreover, long-term observations showed that no substantial cell death occurred at later stages. Neuronal death was induced by standard doses of thymidine analogs, but disappeared when low doses were used. Finally, we demonstrate that the OB grows throughout life. This shows that neuronal selection during OB-neurogenesis does not occur after neurons reached stable positions. Moreover, this suggests that OB neurogenesis does not represent neuronal turnover but lifelong neuronal addition.

Type: Article
Title: Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.44830
Publisher version: https://doi.org/10.7554/eLife.44830
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10095670
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