Montague, PR;
Kishida, KT;
(2018)
Computational Underpinnings of Neuromodulation in Humans.
Cold Spring Harbor Laboratory Symposia on Quantitative Biology
, 83
pp. 71-82.
10.1101/sqb.2018.83.038166.
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Abstract
We summarize a new approach to neuromodulator detection that provides colocalized detection of dopamine, serotonin, and norepinephrine at subsecond timescales and promises to provide submillisecond estimates of the same. The methodology, elastic net electrochemistry, is used to estimate dopamine and serotonin in the striatum of conscious human subjects during active decision-making. We show a proof-of-principle example of the same method working on commercially available depth electrodes in common use for epilepsy monitoring and neurosurgical planning in humans, which further promises to make such electrodes sources of fast neuromodulator information never before available in human subjects. We discuss the implications of this methodology for making direct tests in humans of the computations carried by these three important neuromodulatory systems. The methods also promise great utility in model organisms, but this chapter focuses on the possibilities for human use.
| Type: | Article |
|---|---|
| Title: | Computational Underpinnings of Neuromodulation in Humans |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1101/sqb.2018.83.038166 |
| Publisher version: | https://doi.org/10.1101/sqb.2018.83.038166 |
| Language: | English |
| Additional information: | Copyright © 2018 Montague and Kishida; Published by Cold Spring Harbor Laboratory Press. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10095610 |
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