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Genetic causes of PD: A pathway to disease modification

Toffoli, M; Vieira, SRL; Schapira, AHV; (2020) Genetic causes of PD: A pathway to disease modification. Neuropharmacology , 170 , Article 108022. 10.1016/j.neuropharm.2020.108022. Green open access

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Abstract

The underline neuropathology of Parkinson disease is pleiomorphic and its genetic background diverse. Possibly because of this heterogeneity, no effective disease modifying therapy is available. In this paper we give an overview of the genetics of Parkinson disease and explain how this is relevant for the development of new therapies.

Type: Article
Title: Genetic causes of PD: A pathway to disease modification
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropharm.2020.108022
Publisher version: https://doi.org/10.1016/j.neuropharm.2020.108022
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Disease modifying, GBA1, Genetics, LRRK2, Parkinson disease, SNCA, Therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10095601
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