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Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder

Constable, PA; Ritvo, ER; Ritvo, AR; Lee, IO; McNair, ML; Stahl, D; Sowden, J; ... McPartland, JC; + view all (2020) Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders , 50 pp. 2874-2885. 10.1007/s10803-020-04396-5. Green open access

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Abstract

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

Type: Article
Title: Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10803-020-04396-5
Publisher version: https://doi.org/10.1007/s10803-020-04396-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Autism spectrum disorder, Electroretinogram, b-wave
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10095477
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