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Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy

Cookman, J; Hamilton, V; Price, LS; Hall, SR; Bangert, U; (2020) Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy. Nanoscale , 12 (7) pp. 4636-4644. 10.1039/c9nr08126g. Green open access

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Abstract

Here, we show that the development of nuclei and subsequent growth of a molecular organic crystal system can be induced by electron beam irradiation by exploiting the radiation chemistry of the carrier solvent. The technique of Liquid Cell Electron Microscopy was used to probe the crystal growth of flufenamic acid; a current commercialised active pharmaceutical ingredient. This work demonstrates liquid phase electron microscopy analysis as an essential tool for assessing pharmaceutical crystal growth in their native environment while giving insight into polymorph identification of nano-crystals at their very inception. Possible mechanisms of crystal nucleation due to the electron beam with a focus on radiolysis are discussed along with the innovations this technique offers to the study of pharmaceutical crystals and other low contrast materials.

Type: Article
Title: Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c9nr08126g
Publisher version: https://doi.org/10.1039/C9NR08126G
Language: English
Additional information: © Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10095429
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