D'Silva, A;
Bhuva, AN;
Van Zalen, J;
Bastiaenen, R;
Abdel-Gadir, A;
Jones, S;
Nadarajan, N;
... Sharma, S; + view all
(2020)
Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners.
Frontiers in Physiology
, 11
, Article 232. 10.3389/fphys.2020.00232.
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Abstract
Aims: Marathon running is a popular ambition in modern societies inclusive of non-athletes. Previous studies have highlighted concerning transient myocardial dysfunction and biomarker release immediately after the race. Whether this method of increasing physical activity is beneficial or harmful remains a matter of debate. We examine in detail the real-world cardiovascular remodeling response following competition in a first marathon. / Methods: Sixty-eight novice marathon runners (36 men and 32 women) aged 30 ± 3 years were investigated 6 months before and 2 weeks after the 2016 London Marathon race in a prospective observational study. Evaluation included electrocardiography, cardiopulmonary exercise testing, echocardiography, and cardiovascular magnetic resonance imaging. / Results: After 17 weeks unsupervised marathon training, runners revealed a symmetrical, eccentric remodeling response with 3–5% increases in left and right ventricular cavity sizes, respectively. Blood pressure (BP) fell by 4/2 mmHg (P < 0.01) with reduction in arterial stiffness, despite only 11% demonstrating a clinically meaningful improvement in peak oxygen consumption with an overall non-significant 0.4 ml/min/kg increase in peak oxygen consumption (P = 0.14). / Conclusion: In the absence of supervised training, exercise-induced cardiovascular remodeling in real-world novice marathon runners is more modest than previously described and occurs even without improvement in cardiorespiratory fitness. The responses are similar in men and women, who experience a beneficial BP reduction and no evidence of myocardial fibrosis or persistent edema, when achieving average finishing times.
| Type: | Article |
|---|---|
| Title: | Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphys.2020.00232 |
| Publisher version: | https://doi.org/10.3389/fphys.2020.00232 |
| Language: | English |
| Additional information: | Copyright © 2020 D’Silva, Bhuva, van Zalen, Bastiaenen, Abdel-Gadir, Jones, Nadarajan, Menacho Medina, Ye, Augusto, Treibel, Rosmini, Ramlall, Scully, Torlasco, Willis, Finocchiaro, Papatheodorou, Dhutia, Cole, Chis Ster, Hughes, Sharma, Manisty, Lloyd, Moon and Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | cardiovascular remodeling, athlete’s heart, sports cardiology, endurance exercise, cardiorespiratory fitness, marathon |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10094955 |
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