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Evaluation of Aloe Vera Coated Polylactic Acid Scaffolds for Bone Tissue Engineering

Donate, R; Alemán-Domínguez, ME; Monzón, M; Yu, J; Rodríguez-Esparragón, F; Liu, C; (2020) Evaluation of Aloe Vera Coated Polylactic Acid Scaffolds for Bone Tissue Engineering. Applied Sciences , 10 (7) , Article 2576. 10.3390/app10072576. Green open access

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Abstract

3D-printed polylactic acid (PLA) scaffolds have been demonstrated as being a promising tool for the development of tissue-engineered replacements of bone. However, this material lacks a suitable surface chemistry to efficiently interact with extracellular proteins and, consequently, to integrate into the surrounding tissue when implanted in vivo. In this study, aloe vera coatings have been proposed as a strategy to improve the bioaffinity of this type of structures. Aloe vera coatings were applied at three different values of pH (3, 4 and 5), after treating the surface of the PLA scaffolds with oxygen plasma. The surface modification of the material has been assessed through X-ray photoelectron spectroscopy (XPS) analysis and water contact angle measurements. In addition, the evaluation of the enzymatic degradation of the structures showed that the pH of the aloe vera extracts used as coating influences the degradation rate of the PLA-based scaffolds. Finally, the cell metabolic activity of an in vitro culture of human fetal osteoblastic cells on the samples revealed an improvement of this parameter on aloe vera coated samples, especially for those treated at pH 3. Hence, these structures showed potential for being applied for bone tissue regeneration.

Type: Article
Title: Evaluation of Aloe Vera Coated Polylactic Acid Scaffolds for Bone Tissue Engineering
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/app10072576
Publisher version: https://doi.org/10.3390/app10072576
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: regenerative medicine; additive manufacturing; plasma treatment; coating method; aloe vera extracts; osteoblast cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10094872
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