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Effect of intraocular scattering in macular pigment optical density measurements

Christaras, D; Pennos, A; Ginis, H; Artal, P; (2018) Effect of intraocular scattering in macular pigment optical density measurements. Journal of Biomedical Optics , 23 (5) , Article 056001. 10.1117/1.JBO.23.5.056001. Green open access

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Abstract

Fundus reflectometry is a common in-vivo, noninvasive method to estimate the macular pigment optical density (MPOD). The measured density, however, can be affected by the individual’s intraocular scattering. Scattering causes a reduction in the contrast of the fundus image, which in turn leads to an underestimation of the measured density. Intraocular scattering was measured optically in a group of seven young, healthy subjects using the method of optical integration and was subsequently used to correctly estimate the MPOD from fundus images. It was shown that when scattering is not considered, the measured optical density using fundus reflectometry can be underestimated by as high as 16% for our group of subjects.

Type: Article
Title: Effect of intraocular scattering in macular pigment optical density measurements
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/1.JBO.23.5.056001
Publisher version: https://doi.org/10.1117/1.JBO.23.5.056001
Language: English
Additional information: © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. https://creativecommons.org/licenses/by/3.0/
Keywords: intraocular scattering; straylight; macular pigment; fundus imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10094835
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