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Smoking and COVID-19: Rapid evidence review for the Royal College of Physicians, London (UK)

Simons, D; Brown, J; Shahab, L; Perski, O; (2020) Smoking and COVID-19: Rapid evidence review for the Royal College of Physicians, London (UK). Qeios 10.32388/vgjcun. (In press). Green open access

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Abstract

SARS-CoV-2 is the causative agent of COVID-19, an emergent zoonotic disease which has reached pandemic levels and is designated a public health emergency of international concern by the World Health Organisation. Early data suggest that older age, male sex and a diagnosis of hypertension or diabetes independently increase the risk of hospitalisation and death from COVID-19; however, the biological mechanisms underpinning these associations are currently unclear. The SARS-CoV-2 virus enters human cells through the ACE2 receptor. Current and past tobacco smoking is associated with changes in the ACE2 receptor expression, hypertension, diabetes and worse outcomes following other viral infections. It is hence plausible that smoking is an independent risk factor for hospitalisation and death from COVID-19. Here, we review available evidence for an association between smoking status and hospitalisation for COVID-19. We highlight concerns regarding the quality of available data and call for more systematic collection of smoking status in future studies.

Type: Article
Title: Smoking and COVID-19: Rapid evidence review for the Royal College of Physicians, London (UK)
Open access status: An open access version is available from UCL Discovery
DOI: 10.32388/vgjcun
Publisher version: https://doi.org/10.32388/vgjcun
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/10094820
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