UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

High incidence of Hepatitis C virus infection observed in the PROUD study of HIV pre‐exposure prophylaxis

Desai, M; White, E; Vora, N; Gilson, R; Lacey, C; Gafos, M; Clarke, A; ... Dunn, DT; + view all (2020) High incidence of Hepatitis C virus infection observed in the PROUD study of HIV pre‐exposure prophylaxis. Journal of Viral Hepatitis 10.1111/jvh.13297. (In press). Green open access

[img]
Preview
Text
McCormack_High incidence of Hepatitis C virus infection observed in the PROUD study of HIV pre-exposure prophylaxis_AAM.pdf - Accepted version

Download (8MB) | Preview

Abstract

Abstract HIV negative men who have sex with men (MSM) who access pre‐exposure prophylaxis (PrEP) report sexual behaviours that could place them at high risk of hepatitis C virus infection (HCV). We report HCV prevalence and incidence from the PROUD trial of PrEP.PROUD was an open‐label, wait‐list design randomised trial of HIV PrEP for MSM.Participants were recruited between November 2012 and April 2014, and follow‐up continued to October 2016. Initial HCV testing followed national guidelines, with screening “on indication”, but was replaced by routine quarterly screening in the latter part of the study.We estimated HCV seroprevalence at enrolment and incidence overall and according to calendar year.544 participants were recruited to PROUD. 133 (24.4%) were screened for HCV at enrolment, and 490 (90.1%) were tested at least once during follow‐up. Seroprevalence at enrolment was 2.1% (11/530; 95% CI: 1.0‐3.7%). Median follow‐up time was 2.6 (IQR: 2.1‐3.0) years and total follow‐up of 1188.8 person years (PY). Twenty‐five participants had a new HCV infection during the trial, yielding an incidence rate of 2.1 per 100 PY (25/1188.8; 95% CI: 1.4‐3.1), of which three were re‐infections. There was some evidence that HCV incidence increased over calendar time (P‐value for trend=0.09), reaching an estimated 4.0 per 100 PY (95% CI: 2.0‐8.1)in 2016. In conclusion, participants in PROUD had a high, and possibly increasing, incidence of HCV infection. This high incidence of HCV supports the 2018 BHIVA/BASHH recommendation for quarterly HCV testing among HIV‐negative MSM using PrEP in the UK.

Type: Article
Title: High incidence of Hepatitis C virus infection observed in the PROUD study of HIV pre‐exposure prophylaxis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jvh.13297
Publisher version: https://doi.org/10.1111/jvh.13297
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Hepatitis C, incidence, pre-exposure prophylaxis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10094654
Downloads since deposit
4Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item