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Intensive care for human hearts in pluripotent stem cell models

Golforoush, P; Schneider, MD; (2020) Intensive care for human hearts in pluripotent stem cell models. npj Regenerative Medicine volume , 5 (1) , Article 4. 10.1038/s41536-020-0090-7. Green open access

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Abstract

Successful drug discovery is ultimately contingent on the availability of workable, relevant, predictive model systems. Conversely, for cardiac muscle, the lack of human preclinical models to inform target validation and compound development has likely contributed to the perennial problem of clinical trial failures, despite encouraging non-human results. By contrast, human cardiomyocytes produced from pluripotent stem cell models have recently been applied to safety pharmacology, phenotypic screening, target validation and high-throughput assays, facilitating cardiac drug discovery. Here, we review the impact of human pluripotent stem cell models in cardiac drug discovery, discussing the range of applications, readouts, and disease models employed, along with the challenges and prospects to advance this fruitful mode of research further.

Type: Article
Title: Intensive care for human hearts in pluripotent stem cell models
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41536-020-0090-7
Publisher version: https://doi.org/10.1038/s41536-020-0090-7
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Technology, Cell & Tissue Engineering, Engineering, Biomedical, Cell Biology, Engineering, IPSC-DERIVED CARDIOMYOCYTES, PERCUTANEOUS CORONARY INTERVENTION, MYOCARDIAL-INFARCTION, IN-VITRO, VENTRICULAR CARDIOMYOCYTES, CARDIAC MICROTISSUES, PRECLINICAL MODEL, DRUG SAFETY, CARDIOTOXICITY, REVEALS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10094586
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