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Shed syndecan-2 inhibits angiogenesis

De Rossi, G; Evans, AR; Kay, E; Woodfin, A; McKay, TR; Nourshargh, S; Whiteford, JR; (2014) Shed syndecan-2 inhibits angiogenesis. Journal of Cell Science , 127 (21) pp. 4788-4799. 10.1242/jcs.153015. Green open access

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Abstract

Angiogenesis is essential for the development of a normal vasculature, tissue repair and reproduction, and also has roles in the progression of diseases such as cancer and rheumatoid arthritis. The heparan sulphate proteoglycan syndecan-2 is expressed on mesenchymal cells in the vasculature and, like the other members of its family, can be shed from the cell surface resulting in the release of its extracellular core protein. The purpose of this study was to establish whether shed syndecan-2 affects angiogenesis. We demonstrate that shed syndecan-2 regulates angiogenesis by inhibiting endothelial cell migration in human and rodent models and, as a result, reduces tumour growth. Furthermore, our findings show that these effects are mediated by the protein tyrosine phosphatase receptor CD148 (also known as PTPRJ) and this interaction corresponds with a decrease in active β1 integrin. Collectively, these data demonstrate an unexplored pathway for the regulation of new blood vessel formation and identify syndecan-2 as a therapeutic target in pathologies characterised by angiogenesis.

Type: Article
Title: Shed syndecan-2 inhibits angiogenesis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/jcs.153015
Publisher version: https://doi.org/10.1242/jcs.153015
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
Keywords: AngiogenesisInflammationSyndecanIntegrinEndothelial cell migration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10094430
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