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Critical Factors in Measuring Angiogenesis Using the Aortic Ring Model

De Rossi, G; Scotland, R; Whiteford, J; (2013) Critical Factors in Measuring Angiogenesis Using the Aortic Ring Model. Journal of Genetic Syndromes & Gene Therapy , 4 (5) , Article 147. 10.4172/2157-7412.1000147. Green open access

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Abstract

Angiogenesis is a feature of numerous pathologies including cancer and inflammatory conditions and as such is key therapeutic target for the treatment of disorders where excessive or insufficient formation of new blood vessels occurs. The study of angiogenesis in vivo provides many challenges, however the growth of new blood vessels in vitro from aortic explants has provided a highly useful model for the study of this process. In this manuscript we examine the critical factors which can affect this assay and demonstrate that aortas from both female rats and mice exhibit a reduced angiogenic response to males. These findings have implications not only for the experimental design of angiogenesis experiments but also in the use of therapies targeting angiogenesis in the treatment of pathologies, such as cancer.

Type: Article
Title: Critical Factors in Measuring Angiogenesis Using the Aortic Ring Model
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.4172/2157-7412.1000147
Publisher version: https://doi.org/10.4172/2157-7412.1000147
Language: English
Additional information: © 2013 De Rossi G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Angiogenesis, Aortic ring, Endothelial cell, Gender, Tumour angiogenesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10094428
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