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A novel role for syndecan-3 in angiogenesis

De Rossi, G; Whiteford, JR; (2013) A novel role for syndecan-3 in angiogenesis. F1000Research , 2 , Article 270. 10.12688/f1000research.2-270.v1. Green open access

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Abstract

Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains. The extracellular core proteins of syndecan-1,-2 and -4 all possess adhesion regulatory motifs and we hypothesized that syndecan-3 may also possess such characteristics. Here we show that a bacterially expressed GST fusion protein consisting of the entire mature syndecan-3 ectodomain has anti-angiogenic properties and acts via modulating endothelial cell migration. This work identifies syndecan-3 as a possible therapeutic target for anti-angiogenic therapy.

Type: Article
Title: A novel role for syndecan-3 in angiogenesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.12688/f1000research.2-270.v1
Publisher version: https://doi.org/10.12688/f1000research.2-270.v1
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Angiogenesis, Endothelial Cell, Syndecan, Heparan Sulphate
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10094427
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