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Epilepsy and cannabidiol: a guide to treatment

Arzimanoglou, A; Brandl, U; Cross, JH; Gil-Nagel, A; Lagae, L; Landmark, CJ; Specchio, N; ... The Cannabinoids International Experts Panel, .; + view all (2020) Epilepsy and cannabidiol: a guide to treatment. Epileptic Disorders , 22 (1) pp. 1-14. 10.1684/epd.2020.1141. Green open access

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Abstract

The growing interest in cannabidiol (CBD), specifically a pure form of CBD, as a treatment for epilepsy, among other conditions, is reflected in recent changes in legislation in some countries. Although there has been much speculation about the therapeutic value of cannabis-based products as an anti-seizure treatment for some time, it is only within the last two years that Class I evidence has been available for a pure form of CBD, based on placebo-controlled RCTs for patients with Lennox-Gastaut syndrome and Dravet syndrome. However, just as we are beginning to understand the significance of CBD as a treatment for epilepsy, in recent years, a broad spectrum of products advertised to contain CBD has emerged on the market. The effects of these products are fundamentally dependent on the purity, preparation, and concentration of CBD and other components, and consensus and standardisation are severely lacking regarding their preparation, composition, usage and effectiveness. This review aims to provide information to neurologists and epileptologists on the therapeutic value of CBD products, principally a purified form, in routine practice for patients with intractable epilepsy.

Type: Article
Title: Epilepsy and cannabidiol: a guide to treatment
Location: France
Open access status: An open access version is available from UCL Discovery
DOI: 10.1684/epd.2020.1141
Publisher version: https://doi.org/10.1684/epd.2020.1141
Language: English
Additional information: © 2020 Epileptic Disorders. This is an open access article under the terms of the Creative Commons Attribution‐ShareAlike License (https://creativecommons.org/licenses/by-sa/4.0/).
Keywords: CBD, Dravet, Epidiolex, Epidyolex, Lennox-Gastaut, cannabidiol, cannabis, epilepsy, guidelines, oil
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10094332
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