Obaid, A;
Hanna, M-E;
Wu, Y-W;
Kollo, M;
Racz, R;
Angle, MR;
Müller, J;
... Melosh, NA; + view all
(2020)
Massively parallel microwire arrays integrated with CMOS chips for neural recording.
Science Advances
, 6
(12)
, Article eaay2789. 10.1126/sciadv.aay2789.
Preview |
Text
eaay2789.full.pdf - Published Version Download (2MB) | Preview |
Abstract
Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.
| Type: | Article |
|---|---|
| Title: | Massively parallel microwire arrays integrated with CMOS chips for neural recording |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciadv.aay2789 |
| Publisher version: | http://dx.doi.org/10.1126/sciadv.aay2789 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10094261 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
