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A method for evaluating the cost-benefit of different preparedness planning policies against pandemic influenza

Panovska- Griffiths, J; Grieco, L; van Leeuwen, E; Grove, P; Utley, M; (2020) A method for evaluating the cost-benefit of different preparedness planning policies against pandemic influenza. MethodsX , Article 100870. 10.1016/j.mex.2020.100870. (In press). Green open access

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Abstract

Our work presents a unifying method to calculate the net-benefit of different preparedness policies against different pandemic influeunza strains. Unlike previous methods, which have focused on evaluating specific strategies against specific pandemics, our method allows assessment of mass immunisation under a large range of pandemic influenza strain characteristics and programme features. Overall, the model described here combines two parts to evaluate different preparedness planning policies against pandemic influenza. The first part is adaptation of an existing transmission model for seasonal influenza to include generalisation of large number of pandemic influenza scenarios. The second part is development of a tailor-made health economic model devised in collaboration with colleagues at the UK Department of Health and Social Care. 1. This as a unifying method to calculate the net-benefit of different preparedness policies against different pandemic influeunza strains. 2. We adaptated of an existing transmission model for seasonal influenza to project the impact of different interventions against different influenza strains 3. In collaboration with colleagues at the UK Department of Health and Social Care, we developed a corresponding economic model 4. We can combine the results from 1 and 2 to showcase the net-benefit projections across a large number of scenarios.

Type: Article
Title: A method for evaluating the cost-benefit of different preparedness planning policies against pandemic influenza
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mex.2020.100870
Publisher version: https://doi.org/10.1016/j.mex.2020.100870
Language: English
Additional information: © 2020 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: epidemiological model, economic analysis, pandemic influenza
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics > Clinical Operational Research Unit
URI: https://discovery.ucl.ac.uk/id/eprint/10093910
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