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Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.

Kvavilashvili, L; Niedźwieńska, A; Gilbert, SJ; Markostamou, I; (2020) Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease. Trends in Cognitive Sciences , 24 (4) pp. 285-301. 10.1016/j.tics.2020.01.005.

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Abstract

In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.

Type: Article
Title: Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.
Location: England
DOI: 10.1016/j.tics.2020.01.005
Publisher version: https://doi.org/10.1016/j.tics.2020.01.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Default mode network, involuntary memory, mild cognitive impairment, mind-wandering, posterior cingulate cortex, prospective memory, spontaneous retrieval
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10093887
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