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Syndecan-3 in Inflammation and Angiogenesis

Arokiasamy, S; Balderstone, MJM; De Rossi, G; Whiteford, JR; (2020) Syndecan-3 in Inflammation and Angiogenesis. Frontiers in Immunology , 10 , Article 3031. 10.3389/fimmu.2019.03031. Green open access

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Abstract

Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. Roles for this molecule in both neuronal and brain tissue have been identified, and is associated with altered satiety responses. Recent studies suggest that SDC3 expression is not restricted to neuronal tissues and has important roles in inflammatory disorders such as rheumatoid arthritis, disease associated processes such as angiogenesis and in the facilitation of infection of dendritic cells by HIV. The purpose of this review article is to explore these new biological insights into SDC3 functions in inflammatory disease.

Type: Article
Title: Syndecan-3 in Inflammation and Angiogenesis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2019.03031
Publisher version: https://doi.org/10.3389/fimmu.2019.03031
Language: English
Additional information: Copyright © 2020 Arokiasamy, Balderstone, De Rossi and Whiteford. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: heparan sulfate, syndecan, HIV, rheumatoid arthritis, angiogenesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10093878
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