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Targeting with nanoparticles for the therapeutic treatment of brain diseases

Jin, G-Z; Chakraborty, A; Lee, J-H; Knowles, JC; Kim, H-W; (2020) Targeting with nanoparticles for the therapeutic treatment of brain diseases. Journal of Tissue Engineering , 11 pp. 1-13. 10.1177/2041731419897460. Green open access

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Abstract

Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost. Nanoparticles that load and deliver drugs and genes have been intensively studied for the treatment of brain diseases, and have demonstrated some biological effects in various animal models. Among other efforts taken in the nanoparticle development, targeting of blood brain barrier, specific cell type or local intra-/extra-cellular space is an important strategy to enhance the therapeutic efficacy of the nanoparticle delivery systems. This review underlies the targeting issue in the nanoparticle development for the treatment of brain diseases, taking key exemplar studies carried out in various in vivo models.

Type: Article
Title: Targeting with nanoparticles for the therapeutic treatment of brain diseases
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731419897460
Publisher version: https://doi.org/10.1177/2041731419897460
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Brain diseases, blood brain barrier, in vivo models, nanoparticles, targeting
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10093854
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