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Mucins and their receptors in chronic lung disease

Denneny, E; Sahota, J; Beatson, R; Thornton, D; Burchell, J; Porter, J; (2020) Mucins and their receptors in chronic lung disease. Clinical & Translational Immunology , 9 , Article e1120. 10.1002/cti2.1120. Green open access

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Abstract

There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, and subsequent global morbidity and mortality. Mucins play a critical role in chronic lung disease, not only by providing a physical barrier and clearing pathogens, but also in immune homeostasis. The aim of this review is to familiarise the reader with the role of mucins in both lung health and disease, with particular focus on function in immunity, infection and inflammation. We will also discuss their receptors, termed glycan‐binding proteins, and how they provide an attractive prospect for therapeutic intervention.

Type: Article
Title: Mucins and their receptors in chronic lung disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cti2.1120
Publisher version: https://doi.org/10.1002/cti2.1120
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Keywords: glycan-binding protein, glycosylation, immunology, mucin, pulmonary
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10093838
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