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Estimation of dynamic SNP-heritability with Bayesian Gaussian process models

Arjas, A; Hauptmann, A; Sillanpää, MJ; (2020) Estimation of dynamic SNP-heritability with Bayesian Gaussian process models. Bioinformatics , 36 (12) pp. 3795-3802. 10.1093/bioinformatics/btaa199. Green open access

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Abstract

Motivation: Improved DNA technology has made it practical to estimate single nucleotide polymorphism (SNP)-heritability among distantly related individuals with unknown relationships. For growth and development related traits, it is meaningful to base SNP-heritability estimation on longitudinal data due to the time-dependency of the process. However, only few statistical methods have been developed so far for estimating dynamic SNP-heritability and quantifying its full uncertainty. / Results: We introduce a completely tuning-free Bayesian Gaussian process (GP) based approach for estimating dynamic variance components and heritability as their function. For parameter estimation, we use a modern Markov Chain Monte Carlo (MCMC) method which allows full uncertainty quantification. Several data sets are analysed and our results clearly illustrate that the 95 % credible intervals of the proposed joint estimation method (which "borrows strength" from adjacent time points) are significantly narrower than of a two-stage baseline method that first estimates the variance components at each time point independently and then performs smoothing. We compare the method with a random regression model using MTG2 and BLUPF90 softwares and quantitative measures indicate superior performance of our method. Results are presented for simulated and real data with up to 1000 time points. Finally, we demonstrate scalability of the proposed method for simulated data with tens of thousands of individuals. / Availability: The C++ implementation dynBGP and simulated data are available in GitHub (https://github.com/aarjas/dynBGP). The programs can be run in R. Real datasets are available in QTL archive (https://phenome.jax.org/centers/QTLA). / Supplementary information: Supplementary data are available at Bioinformatics online.

Type: Article
Title: Estimation of dynamic SNP-heritability with Bayesian Gaussian process models
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/bioinformatics/btaa199
Publisher version: https://doi.org/10.1093/bioinformatics/btaa199
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10093709
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