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Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing

Bascone, D; Galvanin, F; Shah, N; Garcia-Munoz, S; (2020) Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing. Industrial and Engineering Chemistry Research , 59 (14) pp. 6650-6661. 10.1021/acs.iecr.0c0042. Green open access

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Abstract

Nowadays, screw feeders are popular equipment in the pharmaceutical industry. However, despite the increasing research in the last decade in the manufacturing of powder-based products, there is still a lack of knowledge on the physics governing the dynamic behaviour of these systems. As a result, data-driven models have often been used to address process design, optimisation and control applications. In this paper, a methodology for the modelling of twin screw feeders has been suggested. A first order plus dead time model has been developed where a hybrid mechanistic-empirical approach has been used. Different powders and two screw feeder geometries have been investigated. The model predictions are in good agreement with the experimental measurements when the 35-mm diameter screws are employed. When the 20 mm- diameter screws are used, the validity range of the model is limited for the least cohesive powders, suggesting that their screw speed-dependant resistance to flow in small screws requires further investigations.

Type: Article
Title: Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing
Location: Orlando
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.iecr.0c0042
Publisher version: https://doi.org/10.1021/acs.iecr.0c0042
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dynamic modelling, Screw feeders, Continuous tablet manufacturing, Pharmaceutical
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10093648
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