Bascone, D;
Galvanin, F;
Shah, N;
Garcia-Munoz, S;
(2020)
Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing.
Industrial and Engineering Chemistry Research
, 59
(14)
pp. 6650-6661.
10.1021/acs.iecr.0c0042.
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Abstract
Nowadays, screw feeders are popular equipment in the pharmaceutical industry. However, despite the increasing research in the last decade in the manufacturing of powder-based products, there is still a lack of knowledge on the physics governing the dynamic behaviour of these systems. As a result, data-driven models have often been used to address process design, optimisation and control applications. In this paper, a methodology for the modelling of twin screw feeders has been suggested. A first order plus dead time model has been developed where a hybrid mechanistic-empirical approach has been used. Different powders and two screw feeder geometries have been investigated. The model predictions are in good agreement with the experimental measurements when the 35-mm diameter screws are employed. When the 20 mm- diameter screws are used, the validity range of the model is limited for the least cohesive powders, suggesting that their screw speed-dependant resistance to flow in small screws requires further investigations.
| Type: | Article |
|---|---|
| Title: | Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing |
| Location: | Orlando |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.iecr.0c0042 |
| Publisher version: | https://doi.org/10.1021/acs.iecr.0c0042 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Dynamic modelling, Screw feeders, Continuous tablet manufacturing, Pharmaceutical |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10093648 |
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