Lamin, A;
Jarrar, Z;
Williams, K;
Garg, A;
Basheer, K;
Sivaprasad, S;
Hammond, C;
(2020)
Segmented macular layer volumes from spectral domain optical coherence tomography in 184 adult twins: associations with age and heritability.
Investigative Ophthalmology & Visual Science
, 61
(5)
, Article 44. 10.1167/iovs.61.5.44.
Preview |
Text
Mahroo_Segmented_Macular_Volumes_Twin_Study_IOVS_2020.pdf - Published Version Download (926kB) | Preview |
Abstract
Purpose: To investigate segmented macular layer volumes from a healthy adult twin cohort (TwinsUK), exploring changes with age and heritability. / Methods: Macular spectral domain optical coherence tomography images were acquired from monozygotic (MZ) and dizygotic (DZ) twins in a cross-sectional study. The following layer volumes were derived for circles of 3 and 6 mm diameter around the foveal center, using automated segmentation software: retinal nerve fiber layer (RNFL), ganglion cell–inner plexiform layer (GCIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptors (PR), retinal pigment epithelium (RPE), and total retinal volume (TRV). Correlation coefficients (intereye; age; intrapair for MZ and DZ pairs) were quantified; heritability was estimated using structural equation modeling. / Results: Scans from 184 participants were included. Intereye correlation was highest for TRV and GCIPL. Negative correlations with age (for 3- or 6-mm areas, or both) were observed for TRV, RNFL, GCIPL, and INL. Positive correlations were observed for PR, RPE, and OPL. For all layers, intrapair correlation was greater for MZ than DZ pairs. Heritability estimates were highest (>80%) for TRV and GCIPL volume, and lowest for RPE volume. / Conclusions: Although TRV was negatively correlated with age, all layers did not show negative correlation. Some inner layers thinned with age, whereas some outer volumes increased (not the ONL). Reduced RPE phagocytic function with age and remodeling in the OPL could be contributing factors. Heritability estimates were highest for inner retinal layers (particularly GCIPL), and lowest for RPE volume.
| Type: | Article |
|---|---|
| Title: | Segmented macular layer volumes from spectral domain optical coherence tomography in 184 adult twins: associations with age and heritability |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1167/iovs.61.5.44 |
| Publisher version: | https://doi.org/10.1167/iovs.61.5.44 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0). |
| Keywords: | retina, macula, photoreceptors, optical coherence tomography, twin study |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10093577 |
Archive Staff Only
 |
View Item |
