UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Remote Ischemic Conditioning in Emergency Medicine—Clinical Frontiers and Research Opportunities

Ho, AFW; Chong, J; Ong, MEH; Hausenloy, DJ; (2020) Remote Ischemic Conditioning in Emergency Medicine—Clinical Frontiers and Research Opportunities. Shock , 53 (3) pp. 269-276. 10.1097/SHK.0000000000001362. Green open access

[thumbnail of Hausenloy_Manuscript 23 Mar 2019 accepted version.pdf]
Preview
Text
Hausenloy_Manuscript 23 Mar 2019 accepted version.pdf - Accepted Version

Download (903kB) | Preview

Abstract

Time-critical acute ischemic conditions such as ST-elevation myocardial infarction and acute ischemic stroke are staples in Emergency Medicine practice. While timely reperfusion therapy is a priority, the resultant acute ischemia/reperfusion injury contributes to significant mortality and morbidity. Among therapeutics targeting ischemia/reperfusion injury (IRI), remote ischemic conditioning (RIC) has emerged as the most promising.RIC, which consists of repetitive inflation and deflation of a pneumatic cuff on a limb, was first demonstrated to have protective effect on IRI through various neural and humoral mechanisms. Its attractiveness stems from its simplicity, low-cost, safety, and efficacy, while at the same time it does not impede reperfusion treatment. There is now good evidence for RIC as an effective adjunct to reperfusion in ST-elevation myocardial infarction patients for improving clinical outcomes. For other applications such as acute ischemic stroke, subarachnoid hemorrhage, traumatic brain injury, cardiac arrest, and spinal injury, there is varying level of evidence.This review aims to describe the RIC phenomenon, briefly recount its historical development, and appraise the experimental and clinical evidence for RIC in selected emergency conditions. Finally, it describes the practical issues with RIC clinical application and research in Emergency Medicine.

Type: Article
Title: Remote Ischemic Conditioning in Emergency Medicine—Clinical Frontiers and Research Opportunities
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/SHK.0000000000001362
Publisher version: http://dx.doi.org/10.1097/SHK.0000000000001362
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10093574
Downloads since deposit
94Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item