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Lasting organ-level bone mechanoadaptation is unrelated to local strain

Javaheri, B; Razi, H; Gohin, S; Wylie, S; Chang, Y-M; Salmon, P; Lee, PD; (2020) Lasting organ-level bone mechanoadaptation is unrelated to local strain. Science Advances , 6 (10) , Article eaax8301. 10.1126/sciadv.aax8301. Green open access

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Abstract

Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and remodeling in vivo. We first confirmed that some acute load-induced structural changes are reversible, adhere to the linear strain magnitude regulation of remodeling activities, and are restricted to bone regions in which marked antiresorptive actions are evident. We make the novel observation that loading exerts significant lasting modifications in tibial shape and mass across extensive bone regions, underpinned by (re)modeling independent of local strain magnitude, occurring at sites where the initial response to load is principally osteogenic. This is the first report to demonstrate that bone loading stimulates nonlinear remodeling responses to strain that culminate in greater curvature adjusted for load predictability without sacrificing strength.

Type: Article
Title: Lasting organ-level bone mechanoadaptation is unrelated to local strain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.aax8301
Publisher version: https://doi.org/10.1126/sciadv.aax8301
Language: English
Additional information: © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10093163
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