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Mesoporous Phosphate-Based Glasses Prepared via Sol–Gel

Foroutan, F; Kyffin, BA; Abrahams, I; Corrias, A; Gupta, P; Velliou, E; Knowles, JC; (2020) Mesoporous Phosphate-Based Glasses Prepared via Sol–Gel. ACS Biomaterials Science & Engineering , 6 (3) pp. 1428-1437. 10.1021/acsbiomaterials.9b01896. Green open access

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Abstract

In the present study, a mesoporous phosphate-based glass (MPG) in the P2O5–CaO–Na2O system was synthesized, for the first time, using a combination of sol–gel chemistry and supramolecular templating. A comparison between the structural properties, bioactivity, and biocompatibility of the MPG with a non-porous phosphate-based glass (PG) of analogous composition prepared via the same sol–gel synthesis method but in the absence of a templating surfactant is also presented. Results indicate that the MPG has enhanced bioactivity and biocompatibility compared to the PG, despite having a similar local structure and dissolution properties. In contrast to the PG, the MPG shows formation of hydroxycarbonate apatite (HCA) on its surface after 24 h of immersion in simulated body fluid. Moreover, MPG shows enhanced viability of Saos-2 osteosarcoma cells after 7 days of culturing. This suggests that textural properties (porosity and surface area) play a crucial role in the kinetics of HCA formation and in interaction with cells. Increased efficiency of drug loading and release over non-porous PG systems was proved using the antibiotic tetracycline hydrochloride as a drug model. This study represents a significant advance in the field of mesoporous materials for drug delivery and bone tissue regeneration as it reports, for the first time, the synthesis, structural characterization, and biocompatibility of mesoporous calcium phosphate glasses.

Type: Article
Title: Mesoporous Phosphate-Based Glasses Prepared via Sol–Gel
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsbiomaterials.9b01896
Publisher version: https://doi.org/10.1021/acsbiomaterials.9b01896
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Mesoporous materials sol−gel phosphate glasses bone regeneration drug delivery
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10093110
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